ATG4D anticorps (N-Term)

N° du produit ABIN6992097

Cet anticorps anti-ATG4D est un anticorps Lapin Polyclonal détectant ATG4D dans WB, ELISA, IF et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour ATG4D anticorps (N-Term) (ABIN6992097)

Antigène: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4D est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ATG4D anticorps

Épitope: N-Term

Specificité: ATG4D antibody is human, mouse and rat reactive. At least two isoforms of ATG4D are known to exist, this antibody will detect only the larger isoform. ATG4D is predicted to not cross-react with other ATG4 proteins.

Purification: ATG4D antibody is affinity chromatography purified via peptide column.

Immunogène: ATG4D antibody was raised against a 17 amino acid peptide near the amino terminus of human ATG4D. The immunogen is located within the first 50 amino acids of ATG4D.

Isotype: IgG

Information d'application

Indications d'application: ATG4D antibody can be used for detection of ATG4D by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATG4D antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ATG4D antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur ATG4D

Antigène: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Autre désignation: ATG4D

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4D, also known as AUTL4, is one of four mammalian orthologs of the yeast ATG4 protein, all four are cysteine proteases (3). ATG4 is required for ATG8 conjugation to phosphatidylethanolamine on autophagosomal membranes. In mammals, each ATG4 homolog shows a selective preference for the ATG8 homologs (4).

Poids moléculaire: Predicted: 52 kDa

Observed: 49 kDa

ID gène: 84971

NCBI Accession: NP_116274

UniProt: Q86TL0

Pathways: Autophagy